HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoro-2-methylaniline → 2-(4-Fluoro-2-methylphenylamino)-4-(N-methylphenylamino)thieno-[2,3-d]pyrimidine hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoro-2-methylaniline | HCID 67982 | — |
| Reactant | 2-Chloro-4-(N-methylphenylamino)thieno[2,3-d]pyrimidine | HCID 10356057 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-(4-Fluoro-2-methylphenylamino)-4-(N-methylphenylamino)thieno-[2,3-d]pyrimidine hydrochloride | HCID 19104028 | — |
Reaction Steps
2-Chloro-4-(N-methylphenylamino)thieno[2,3-d]-pyrimidine (1.5 g, 0.00544 mol) and 4-fluoro-2-methylphenylamine (1.5 g, 0.0120 mol) were heated at 160° for 2.5 hours. Addition of methanol gave a solid which was collected by filtration and dried, (1.81 g). Recrystallization from ethanolic HCl/methanol gave the title compound as the hydrochloride salt, (1.44 g), m.p.216°-218°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05280026 |
| Source dataset | uspto-grants-1994_01 |
| ORD ID | ord-5697d0d765ec49ebaa842b600742f1fb |
| Source note | uspto-grants-1994_01 |