O-Toluidine → HCID 67850558, compound

HRID 1198116Notes

Reaction equation

HRID 1198116 reaction equation
[Cl:1][C:2]1[N:3]=[C:4]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:5]2[CH:10]=[CH:9][S:8][C:6]=2[N:7]=1.[NH2:18][C:19]1[C:20]([CH3:25])=[CH:21][CH:22]=[CH:23][CH:24]=1>C(OCC)C>[ClH:1].[CH3:25][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=1[NH:18][C:2]1[N:3]=[C:4]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[C:5]2[CH:10]=[CH:9][S:8][C:6]=2[N:7]=1

Participants

4

Reactant 2

HCID 7242O-ToluidineHCID 10467855HCID 10467855, compound

Product 1

HCID 67850558HCID 67850558, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

2-Chloro-4-(phenylamino)thieno[2,3-d]pyrimidine (3 g, 0.0115 mol) and o-toluidine (2.46 g, 0.023 mol) were heated at 140° for 3 hours. Addition of diethyl ether gave a solid which was collected by filtration and dried, (3.7 g). Recrystallization from ethanolic HCl gave the title compound as the hydrochloride salt, (1.67 g), m.p. 232°-234°.

Workup

  1. customgave a solid which
  2. filtrationwas collected by filtration
  3. customdried
  4. customRecrystallization from ethanolic HCl

Sources & evidence

ORD record
ord-e4a47ef754a244f197112804504116d7
Source dataset
uspto-grants-1994_01
Patent number
US05280026

Reaction notes

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