Hydrochloric Acid → HCID 131718310, compound

Participants

Reaction Steps

A mixture of tetraethyl 4-(2-pyridyloxy)butylaminomethylenebisphosphonate (0.85 g) and conc. hydrochloric acid (10 ml) was heated for 2 hours under reflux. The reaction mixture was concentrated under reduced pressure. The concentrate was treated with methanol to give a solid matter, which was recrystallized from water-methanol to give 4-(2-pyridyloxy)butylaminomethylenebisphosphonic acid hydrochloride hemihydrate (0.471 g, 65%), m.p. 155° C. to 157° C.

Provenance & Evidence