Methanol → HCID 86747508, compound

Participants

Reaction Steps

4-(2-Pyridyloxy)butylaminomethylenebisphosphonic acid hydrochloride (1.1 g) was dissolved in water (25 ml), to which was added an aqueous solution of sodium hydroxide (1N, 3 ml). To the mixture was added methanol to cause precipitation of a solid matter, which was collected by filtration and recrystallized from water-methanol to afford 4-(2-pyridyloxy)butylaminomethylenebisphosphonic acid trihydrate (0.6 g, 51%) as colorless crystals, m.p. 186° C. to 187° C.

Provenance & Evidence