Bromotrimethylsilane → HCID 131718314, compound

Participants

Reaction Steps

To a solution of tetraethyl 3-methylthiopropylaminomethylenebisphosphonate (5.28 g) in acetonitrile (100 ml) was added bromotrimethylsilane (12.39 g) and the mixture was stirred at room temperature for 15 hours. The reaction mixture was diluted with water (3.2 ml) and concentrated under reduced pressure. The solid residue was collected by filtration and recrystallized from water-methanol to give 3-methylthiopropylaminomethylenebisphosphonic acid hemihydrate (1.84 g, 47%). Colorless prisms, m.p. 120°-122° C.

Provenance & Evidence