HCID 131718316, compound → HCID 131718315, compound

HRID 1198127Notes

Reaction equation

HRID 1198127 reaction equation
O.O.O.[Na+:4].[Na+].[Na+].[CH3:7][O:8][CH2:9][CH2:10][CH2:11][NH:12][CH:13]([P:18](=[O:21])([O-:20])[O-:19])[P:14](=[O:17])([OH:16])[O-:15]>O>[OH2:8].[Na+:4].[CH3:7][O:8][CH2:9][CH2:10][CH2:11][NH:12][CH:13]([P:14](=[O:15])([OH:16])[O-:17])[P:18](=[O:19])([OH:20])[OH:21].[CH3:7][O:8][CH2:9][CH2:10][CH2:11][NH:12][CH:13]([P:14](=[O:15])([OH:16])[O-:17])[P:18](=[O:19])([OH:20])[OH:21].[Na+:4]

Participants

3

Reactant 1

HCID 131718316HCID 131718316, compound

Product 1

HCID 131718315HCID 131718315, compoundYield 130.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In water (5 ml) was dissolved 3-methoxypropylaminomethylenebisphosphonic acid trisodium salt trihydrate (1.0 g), and the solution was passed through a column packed with Amberlite CG-50 (H+ type, 75 ml). Elution was conducted with water. From the acidic fraction thus eluted, 3-methoxypropylaminomethylenebisphosphonic acid monosodium salt hemihydrate (0.67 g, 87%) was obtained as colorless prisms, m.p. 277°-279° C.

Workup

  1. washElution
  2. washFrom the acidic fraction thus eluted

Sources & evidence

ORD record
ord-ea18026dfea44db0ba18b629f48b474e
Source dataset
uspto-grants-1994_01
Patent number
US05280022

Reaction notes

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