HCID 19104007, compound → HCID 19104018, compound

HRID 1198132Notes

Reaction equation

HRID 1198132 reaction equation
[Cl:1][C:2]1[C:3]([NH:11][CH:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH3:13])=[N:4][CH:5]=[N:6][C:7]=1[CH:8](Cl)[CH3:9].[CH3:20][OH:21].C[O-].[Na+]>CO>[Cl:1][C:2]1[C:3]([NH:11][CH:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH3:13])=[N:4][CH:5]=[N:6][C:7]=1[CH:8]([O:21][CH3:20])[CH3:9]

Participants

4

Reactant 2

HCID 19104007HCID 19104007, compoundHCID 23694274Sodium methanolate methanol

Product 1

HCID 19104018HCID 19104018, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

In 20 ml of methanol was dissolved 1.11 g of 5-chloro-6-(1-chloroethyl)-4-(1-phenylethylamino)pyrimidine, and to the mixture was added 1.3 g of a 28% sodium methoxide methanol solution. The mixture was stirred at 60° C. for 13 hours.

Sources & evidence

ORD record
ord-59bf94c67ee94707bf9413c570fdad1b
Source dataset
uspto-grants-1994_01
Patent number
US05280025

Reaction notes

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