(Diethylamino)sulfur trifluoride → HCID 21758699, compound

HRID 1198134Notes

Reaction equation

HRID 1198134 reaction equation
[Cl:1][C:2]1[C:3]([NH:11][CH:12]([C:14]2[CH:19]=[CH:18][C:17]([S:20][CH3:21])=[CH:16][CH:15]=2)[CH3:13])=[N:4][CH:5]=[N:6][C:7]=1[CH:8](O)[CH3:9].C(N(S(F)(F)[F:28])CC)C>ClCCl>[Cl:1][C:2]1[C:3]([NH:11][CH:12]([C:14]2[CH:19]=[CH:18][C:17]([S:20][CH3:21])=[CH:16][CH:15]=2)[CH3:13])=[N:4][CH:5]=[N:6][C:7]=1[CH:8]([F:28])[CH3:9]

Participants

4

Reactant 2

HCID 123472(Diethylamino)sulfur trifluorideHCID 21758700HCID 21758700, compound

Product 1

HCID 21758699HCID 21758699, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In 80 ml of dichloromethane was dissolved 4.7 g of 5-chloro-6-(1-hydroxyethyl)-4-[1-(4-methylthiophenyl)ethylamino]pyrimidine, and to the mixture was added dropwise 2.6 g of diethylaminosulfur trifluoride under ice cooling. The mixture was stirred at room temperature for 1 hour.

Sources & evidence

ORD record
ord-6b323e27de454c6d8377fc0b1c144141
Source dataset
uspto-grants-1994_01
Patent number
US05280025

Reaction notes

Loading…