HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1198147Generated: October 26, 2026
Ethanolamine → 1-Methyl-N-(2-hydroxyethyl)-piperidine-4-carboxylic acid amide
https://huagongshe.com/reaction/1198147
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanolamine | HCID 700 | — |
| Reactant | Ethyl 1-methylpiperidine-4-carboxylate | HCID 11062856 | — |
| Solvent | Dichloromethane methanol | HCID 21226129 | — |
| Product | 1-Methyl-N-(2-hydroxyethyl)-piperidine-4-carboxylic acid amide | HCID 15068850 | 52% |
Reaction Steps
17.1 g. (0.1 mole) 1-Methylpiperidine-4-carboxylic acid ethyl ester (literature: J.A.C.S., 74, 3831/1952). are heated to 60° C. for 48 hours with 9 ml. (0.15 mole) 2-hydroxyethylamine and purified over a silica gel column with methylene chloride/methanol (9:1 v/v). There are obtained 9.5 g. of base in the form of a viscous oil. Yield 52% of theory.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05280031 |
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| Source dataset | uspto-grants-1994_01 |
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| ORD ID | ord-a98fb4dd781e47c7b6c27cfdeefd3917 |
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| Source note | uspto-grants-1994_01 |
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