HCID 10336689, compound → HCID 10402603, compound

Participants

Reaction Steps

To a stirred solution of 3.8 g (0.0115 moles) of ethyl (Z)-5-[1-phenyl-2-(imidazol-1-yl)-ethylidene]aminoxypentanoate in 20 ml of ethanol, 35 ml of aqueous sodium hydroxyde 1N are added at room temperature. Stirring is continued for 2 hours, and ethanol is removed under vacuum without heating. The aqueous solution is acidified with acetic acid till pH 6 with external cooling. The precipitated product is filtered, washed with ether and filtered again, yielding 2.63 g (75%) of (Z)-5-[1-phenyl-2-(imidazol-1-yl)-ethylidene]aminoxypentanoic acid.

Provenance & Evidence