Water → 4-[1-Hydroxycyclohex1-yl-1-(imidazolyl)methyl]benzonitrile

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Reaction Steps

1.83 g of 4-[1-(imidazolyl)methylbenzonitrile is dissolved in 50 ml of tetrahydrofuran and combined at -50° with 7.3 ml of 1.5-molar solution of lithium diisopropylamide in tetrahydrofuran; the mixture is stirred for 0.5 hour, further stirred with 1.05 g of cyclohexanone for 1 hour at -60°, and heated to 25°. Then water is added, the mixture is diluted with ethyl acetate, washed neutral with water, dried over sodium sulfate, and concentrated to dryness under vacuum, yielding 2.7 g of crude 4-[1-hydroxycyclohex-1-yl-1-(imidazolyl)methyl]benzonitrile.

Provenance & Evidence