HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 4-(Azidomethyl)benzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 4-(Bromomethyl)benzonitrile | HCID 86996 | — |
| Solvent | 1,3-Dimethyl-2-imidazolidinone | HCID 6661 | — |
| Product | 4-(Azidomethyl)benzonitrile | HCID 11073691 | 96.7% |
Reaction Steps
50 g of 4-bromomethylbenzonitrile is dissolved in 350 ml of 1,3-dimethyl-2-imidazolidinone and stirred at 25° for 2 hours with 32.5 g of sodium azide. The mixture is subsequently combined with 500 ml of water under ice cooling, extracted twice with dichloromethane, washed with water, dried over sodium sulfate, concentrated to dryness under vacuum, and chromatographed on silica gel with hexane/ethyl acetate, thus obtaining 39 g of 4-azidomethylbenzonitrile as a colorless liquid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05280035 |
| Source dataset | uspto-grants-1994_01 |
| ORD ID | ord-1485f29b90fe4d12ae1dcc678dcf15cc |
| Source note | uspto-grants-1994_01 |