HCID 15752298, compound → HCID 135674998, compound

Participants

Reaction Steps

Using an analogous procedure to that described in Example 19, pentafluorophenyl p-[N-(7-bromo-2-methyl-4-oxo-3-(pivaloyloxymethyl)-3,4-dihydroquinazolin-6-ylmethyl)-N-(prop-2-ynyl)amino]benzoate was reacted with 2-amino-2-(3-nitrophenyl)ethanol and the pivaloyloxymethyl protecting group was removed from the resultant product to give p-[N-(7-bromo-2-methyl-4-oxo-3,4-dihydroquinazolin-6-ylmethyl)-N-(prop-2-ynyl)amino]-N-[2-hydroxy-1-(3-nitrophenyl)ethyl]benzamide (containing 0.25 equivalents of water) in 61% yield, m.p. 221°-232° C.

Provenance & Evidence