Cycloheximide → 2-[2-(N,N-dimethylamino)ethoxy]-1-[1-(tetrahydropyran-2-yloxy)indan-5-yl]ethanol

HRID 1198264Notes

Reaction equation

HRID 1198264 reaction equation
C[C@@H]1C[C@@H]([C@H](O)CC2C[C:16](=O)[NH:15][C:13](=O)C2)C(=O)[C@@H](C)C1.[CH2:21]([O:28][C:29]1C=C2C(=CC=1)C=C(C=O)C=C2)[C:22]1C=CC=CC=1.[CH:41]([C:43]1[CH:44]=[C:45]2[C:49](=[CH:50][CH:51]=1)[CH:48]([O:52][CH:53]1[CH2:58][CH2:57][CH2:56][CH2:55][O:54]1)[CH2:47][CH2:46]2)=[O:42]>>[CH3:13][N:15]([CH2:22][CH2:21][O:28][CH2:29][CH:41]([C:43]1[CH:44]=[C:45]2[C:49](=[CH:50][CH:51]=1)[CH:48]([O:52][CH:53]1[CH2:58][CH2:57][CH2:56][CH2:55][O:54]1)[CH2:47][CH2:46]2)[OH:42])[CH3:16]

Participants

4

Reactant 3

HCID 6197CycloheximideHCID 53819625HCID 53819625, compoundHCID 54479667HCID 54479667, compound

Product 1

HCID 542682892-[2-(N,N-dimethylamino)ethoxy]-1-[1-(tetrahydropyran-2-yloxy)indan-5-yl]ethanol

Procedure

The same procedure as in (1) and (2) of Production Example 28 was repeated, except that the 6-benzyloxy-2-naphthaldehyde was replaced by 5-formyl-1-(tetrahydropyran-2-yloxy)indane, to obtain oily 2-[2-(N,N-dimethylamino)ethoxy]-1-[1-(tetrahydropyran-2-yloxy)indan-5-yl]ethanol (compound No. 294).

Sources & evidence

ORD record
ord-9489706a12ea4a96a72461c7e713be47
Source dataset
uspto-grants-1994_01
Patent number
US05280032

Reaction notes

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