Sodium Methoxide → HCID 67783632, compound

HRID 1198283Notes

Reaction equation

HRID 1198283 reaction equation
[CH3:1][O-:2].[Na+].[NH2:4][CH:5]1[N:10]=[C:9]([Cl:11])[N:8]=[C:7](F)[N:6]1[O:13][CH:14]([F:16])[F:15]>CO>[NH2:4][CH:5]1[N:10]=[C:9]([Cl:11])[N:8]=[C:7]([O:2][CH3:1])[N:6]1[O:13][CH:14]([F:16])[F:15]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 67783290HCID 67783290, compound

Product 1

HCID 67783632HCID 67783632, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
0 °C

Procedure

8.4 g (0.047 mol) of 30% strength sodium methylate were added over the course of 15 minutes to a stirred mixture of 10 g (0.047 mol) of 2-amino-4-chlorodifluoromethoxy-6-fluoro-1,3,5-triazine and 100 ml of methanol at 0° C. The mixture was stirred at 0° C. for one hour and then concentrated under reduced pressure, taken up in methylene chloride and extracted with water. Drying and concentration yielded 10.4 g (98.5% of theory) of the title compound of melting point 109°-110° C.

Workup

  1. concentrationconcentrated under reduced pressure
  2. extractionextracted with water
  3. customDrying
  4. concentrationconcentration

Sources & evidence

ORD record
ord-70de39a7802b45e7ab48e3b06f8bcdc1
Source dataset
uspto-grants-1994_01
Patent number
US05280118

Reaction notes

Loading…