Methylamine → 2-Amino-4-methylamino-6-trifluoromethoxy-1,3,5-triazine

Participants

Reaction Conditions

Reaction Steps

3.5 g (0.111 mol) of methylamine were passed over the course of 20 minutes into a stirred solution of 11 g (0. 055 mol) of 2-amino-4-fluoro-6-trifluoromethoxy-1, 3,5-triazine in 150 ml of tetrahydrofuran at 0° C. The mixture it was stirred at 0° C. for one hour and at 22° C. overnight. was then concentrated under reduced pressure, stirred with water and dried. 10.8 g (93.1% of theory) of the title compound of melting point 155°-157° C. (decomposition) were obtained.

Provenance & Evidence