Dimethylamine → HCID 67783643, compound

HRID 1198289Notes

Reaction equation

HRID 1198289 reaction equation
[CH3:1][NH:2][CH3:3].[NH2:4][CH:5]1[N:10]=[C:9]([Cl:11])[N:8]=[C:7](F)[N:6]1[O:13][CH:14]([F:16])[F:15]>C(OCC)C>[NH2:4][CH:5]1[N:10]=[C:9]([Cl:11])[N:8]=[C:7]([N:2]([CH3:3])[CH3:1])[N:6]1[O:13][CH:14]([F:16])[F:15]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 67783290HCID 67783290, compound

Product 1

HCID 67783643HCID 67783643, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Conditions

Temperature
22 °C

Procedure

4.2 g (0.093 mol) of dimethylamine were passed over the course of 20 minutes into a stirred solution of 10 g (0.047 mol) of 2-amino-4-chlorodifluoromethoxy-6-fluoro-1,3,5-triazine in 150 ml of diethyl ether at 0° C. The mixture was stirred at 0° C. for one hour and at 22° C. overnight. Washing with water, drying and concentration yielded 9.8 g (87.8% of theory) of the title compound of melting point 130°-133° C. (decomposition).

Workup

  1. washWashing with water
  2. customdrying
  3. concentrationconcentration

Sources & evidence

ORD record
ord-d841bd7e1ae14218a8971dc173e45754
Source dataset
uspto-grants-1994_01
Patent number
US05280118

Reaction notes

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