HCID 19103676, compound → HCID 178447891, compound

Participants

Reaction Steps

A mixture of 10 mmol of 1-(2,3,4-trifluorophenyl)-4-propylcyclohex-1-ene (prepared from 2,3,4-trifluophenyllithium and 4-propylcyclohexanone and subsequent dehydration with p-toluenesulfonic acid), 0.1 g of palladium-on-active charcoal (1%) and 15 ml of toluene is hydrogenated to saturation at room temperature. After filtration and removal of the solvent, the residue is dissolved in 15 ml of dimethyl sulfoxide, 1.2 g of potassium tert.-butanolate are added and the mixture is stirred at room temperature for 2 hours. Acidification and customary working up give trans-1-(2,3,4-trifluorophenyl)-4-propylcyclohexane.

Provenance & Evidence