Oxalic Acid → 4-(4-Pentylbenzoyloxy)-2,3-difluorobenzonitrile

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Reaction Steps

A mixture of 0.11 mol of dicyclohexylcarbodiimide and 20 ml of toluene is added to a mixture of 0.1 mol of p-pentylbenzoic acid, 0.1 mol of 2,3-difluoro-4-cyanophenol (prepared according to Example 4), 1.5 g of 4-N,N-dimethylaminopyridine and 200 ml of toluene. After the mixture has been stirred at room temperature for 4 hours, 0.4 g of oxalic acid is added and stirring is continued for a further 30 minutes. Customary working up gives 4-(4-pentylbenzoyloxy)-2,3-difluorobenzonitrile, mp. 33° C.

Provenance & Evidence