1-Hexyne → HCID 178442536, compound

Participants

Reaction Steps

10 ml of a 20% solution of diisobutylaluminium hydride in hexane are added to a solution of 0.01 mol of 1-hexyne and 5 ml of hexane and the mixture is heated at 50° for 3 hours. It is then cooled to 25°, 6.3 ml of a 15% solution of butyllithium in hexane are added dropwise, after 30 minutes 0.01 mol of 2,3-difluoro-4-(trans-4-pentylcyclohexyl)-methoxybenzyl bromide, dissolved in 15 ml of tetrahydrofuran, are added dropwise and the mixture is heated under reflux for 12 hours. Working up gives 2,3-difluoro-4-(trans-4-pentylcyclohexyl)-methoxy-trans-hept-2-enylbenzene.

Provenance & Evidence