Dicyclohexylcarbodiimide → HCID 14512163, compound

Participants

Reaction Steps

A solution of 0.1 mol of DCC in methylene chloride is added to a mixture of 0.1 mol of 4'-heptyloxy-2,3-difluorobiphenyl-4-ol, 0.1 mol of optically active 2-chloro-3-methylbutyric acid (prepared from valine) and a catalytic amount of DMAP in 250 ml of methylene chloride at 0° C. The mixture is then stirred at room temperature for 12 hours, the precipitate is subsequently filtered off with suction and the filtrate is worked up in the customary manner to give 4-(p-heptyloxyphenyl)-2,3-difluorophenyl 2-chloro-3-methylbutyrate.

Provenance & Evidence