HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1198334Generated: October 31, 2026
p-Toluenesulfonic acid → HCID 19103502, compound
https://huagongshe.com/reaction/1198334
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | N,N,N',N'-Tetramethylethylenediamine | HCID 8037 | — |
| Reactant | Hexane | HCID 8058 | — |
| Reactant | 1-Ethoxy-2,3-Difluorobenzene | HCID 2782928 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Toluene | HCID 1140 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 19103502 | HCID 19103502 | — |
Reaction Steps
66 ml of a 1.6N solution of butyllithium in n-hexane are added dropwise to a solution of 0.1 mol of 2,3-difluorophenetole and 0.1 mol of TMEDA in 200 ml of THF at -70° C. After stirring for 4 hours at -70° C. 0.1 mol of 4-acetyl-4'-propylbiphenyle in 50 ml of THF are added. After customary working up the product and 2 g of p-toluenesulfonic acid are dissolved in 200 ml of toluene and the mixtung is heated under reflux for 0.5 hours. Working up gives 1-(4-ethoxy-2,3-difluorphenyl)-1-(4'-propylbiphenyl-4-yl)-ethene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05279764 |
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| Source dataset | uspto-grants-1994_01 |
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| ORD ID | ord-da8af42da2924c5d9cd76648d268cba9 |
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| Source note | uspto-grants-1994_01 |
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