Triethylamine → 4-[(4-Ethoxy-2,3-difluorophenyl)ethynyl]-4'-propyl-1,1'-biphenyl

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Reaction Steps

0.065 mol of bromine are added to a stirred solution of 0.065 mol of this ethen derivative in a mixture of 100 ml of dichloromethane and 50 ml of acetonitrile. After addition of 10 g of triethylamine and customary working up the crude product is dissolved in 50 ml of THF. 0.13 mol of lithium diisopropylamide in 120 ml of THF are added dropwise to this solution at -50° C. Customary working up gives 1-(4-Ethoxy-2,3-difluorophenyl)-2-(4'-propylbiphenyl-4-yl)-ethine.

Provenance & Evidence