Hydrochloric Acid → HCID 19102635, compound

Participants

Reaction Steps

Aqueous HCl (300 ml, 0.5N) was added to a stirred solution of 5-(1-ethoxyethoxy)-4-(4-methylpiperazinylmethyl)-1,3-benzodioxole (16.0 g, 49.7 mmol) in 2-propanol (300 ml) at room temperature, and stirring was continued for 15 minutes. The solution was extracted with diethyl ether, the aqueous layer was neutralised (pH=7) by adding aqueous NaOH(2N), and the water layer was evaporated in vacuo. The residue was extracted with diethyl ether (3 times). The combined organic layers were dried over Na2SO4, filtered and evaporated in vacuo to yield a crude oil (9.6 g). This oil was purified by flash chromatography (eluent: acetone/ethyl acetate=1/1 (v/v)) to yield 5-hydroxy-4-(4-methylpiperazinylmethyl)-1,3-benzodioxole (7.6 g, 61% yield, compound No. 8) as a solid, m.p. 85°-87° C.

Provenance & Evidence