HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methylhydrazine → 3-(2,5-difluorophenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methylhydrazine | HCID 6061 | — |
| Reactant | 1-(2,5-Difluorophenyl)-4,4,4-trifluorobutane-1,3-dione | HCID 15278558 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 3-(2,5-difluorophenyl)-1-methyl-5-(trifluoromethyl)-1H-pyrazole | HCID 15278559 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
34.5 g of 1-(2,5-difluorophenyl)-3-(trifluoromethyl)-propane-1,3-dione was dissolved in 250 ml of acetic acid and 9.5 mL of methylhydrazine slowly added. The mixture was heated at 100° C. for 5 minutes then cooled and diluted with ether. The ether solution was washed with water and potassium carbonate solution, then dried with magnesium sulfate, filtered and concentrated. The residue was chromatographed to give 9.5 g of 3-(2,5-difluorophenyl)-1-methyl-5-(trifluoro-methyl)-1H-pyrazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05281571 |
| Source dataset | uspto-grants-1994_01 |
| ORD ID | ord-a1144cefd6504c70a927c59c044195c6 |
| Source note | uspto-grants-1994_01 |