反应详情

To a mixture of 2.0 g of 3-carbethoxy-4-piperidone hydrochloride and 20 ml of 1M sodium carbonate is cooled in an ice bath and rapidly treated with 1.3 ml of trimethylacetyl chloride. Stirring is continued in the cold for 1.5 hours. The reaction mixture is filtered and the collected solid washed with water, air dried and then dried at 56° C. for 1.25 hours under high vacuum to afford 1.4 g of the desired product as a colorless solid, m.p. 46°-50° C.

1. temperatureis cooled in an ice bath
2. customcold for 1.5 hours
3. filtrationThe reaction mixture is filtered
4. washthe collected solid washed with water, air
5. customdried
6. customdried at 56° C. for 1.25 hours under high vacuum