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Acetic Anhydride → Ethyl 1-acetyl-4-oxo-3-piperidinecarboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Acetic Anhydride | HCID 7918 | — |
| 反応物 | 4-Oxo-piperidine-3-carboxylic acid ethyl ester | HCID 107316 | — |
| 溶媒 | Sodium Carbonate | HCID 10340 | — |
| 生成物 | Ethyl 1-acetyl-4-oxo-3-piperidinecarboxylate | HCID 12445847 | — |
反応手順
To a vigorously stirred, ice-water cooled suspension of 2.0 g of 3-carbethoxy-4-piperidone in 20 ml of aqueous sodium carbonate is added 1 ml of acetic anhydride. The mixture is stirred in the cold for 30 minutes then extracted with ether. The organic layer is dried and evaporated to afford 1.5 g of colorless solid, m.p. 53°-55° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05281602 |
| 出典データセット | uspto-grants-1994_01 |
| ORD ID | ord-a5433ca7aab142e2b391e1c03e0af46d |
| 出典メモ | uspto-grants-1994_01 |