HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 10036479, compound → 6-Amino-1,2,3,4-tetrahydroquinoline-8-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 10036479 | HCID 10036479 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-Amino-1,2,3,4-tetrahydroquinoline-8-carboxylic acid | HCID 14988473 | 96.8% |
Reaction Steps
A solution of 6-nitro-1,2,3,4-tetrahydroquinoline-8-carboxylic acid (4.5 g) in DMF (200 ml) was hydrogenated in the presence of 10% palladium on charcoal (1 g) for 5 hours. After removal of the catalyst by filtration, solvent was distilled away to give the title compound (3.72 g, 96.8%). This compound was recrystallized from DMF-ethanol to give brown crystals, mp 207-208° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05281600 |
| Source dataset | uspto-grants-1994_01 |
| ORD ID | ord-26ad5f936a2d4430a588d913053c6780 |
| Source note | uspto-grants-1994_01 |