Allyl bromide → HCID 70045243, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 114 (8.0 g, 24.2 mmol), and THF (180 mL) at -78° C. was added LDA (50 mL, 25 mmol, 0.5M/THF) dropwise. After 15 min. allyl bromide (2.3 mL, 26.6 mmol) was added. After 1.0 hour, the reaction mixture was allowed to warm to 0° C. over a 10 min. period. The reaction mixture was diluted with ethyl acetate and then washed with 5% KHSO4 and brine, dried (MgSO4) and concentrated. Flash chromatography (silica, 50% ethyl acetate/hexanes) gave 115.

Provenance & Evidence