2-Furancarbonyl chloride → HCID 19102706, compound

HRID 1198511Notes

Reaction equation

HRID 1198511 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]3[NH:14][C:13]4[CH2:15][CH2:16][NH:17][CH2:18][C:12]=4[C:7]=3[CH:8]=[N:9]2)=[CH:4][CH:3]=1.[O:19]1[CH:23]=[CH:22][CH:21]=[C:20]1[C:24](Cl)=[O:25]>>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6]3[NH:14][C:13]4[CH2:15][CH2:16][N:17]([C:24]([C:20]5[O:19][CH:23]=[CH:22][CH:21]=5)=[O:25])[CH2:18][C:12]=4[C:7]=3[CH:8]=[N:9]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 682422-Furancarbonyl chlorideHCID 14069786HCID 14069786, compound

Product 1

HCID 19102706HCID 19102706, compoundYield 17.6%

Procedure

The same reaction procedure and workup is followed as for the compound of Example 8 using 0.50 g (1.94 mmol) of 3-chloro-8,9,10,11-tetrahydro-7H-pyrido[3',4':4,5]pyrrolo[3,2-c]quinoline and 0.253 g (1.94 mmol) of 2-furoylchloride to yield 0.12 g (17%) of the title compound as a white solid: m.p >250° C.; m/e 351.

Workup

  1. customThe same reaction procedure and workup

Sources & evidence

ORD record
ord-ba4eab81582e45b9a6c4fb689347206c
Source dataset
uspto-grants-1994_01
Patent number
US05281608

Reaction notes

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