HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 3-[(E)-2-(7-Chloroquinolin-2-yl)ethenyl]benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Hexane | HCID 8058 | — |
| Reactant | Isophthalaldehyde | HCID 34777 | — |
| Reactant | 7-Chloro-2-methylquinoline | HCID 138395 | — |
| Solvent | O-Xylene | HCID 7237 | — |
| Product | 3-[(E)-2-(7-Chloroquinolin-2-yl)ethenyl]benzaldehyde | HCID 10017305 | — |
Reaction Steps
A stirred solution of 7-chloroquinaldine [J. Org. Chem. 42, 911 (1977)] (4.46 g, 25 mmol) and isophthalaldehyde (5.02 g, 37.5 mmol) in acetic anhydride (7.1 ml, 75 mmol) and xylene (25 ml) was heated under reflux for 7 hours. Crystals formed on cooling. Hexane (25 ml) was added slowly to give crude product, m.p. 146°-150°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05281593 |
| Source dataset | uspto-grants-1994_01 |
| ORD ID | ord-c84e116f4dac4b9cb1e737deb526ed82 |
| Source note | uspto-grants-1994_01 |