反应详情

4-Phenylbutyronitrile (12.7 g) was added dropwise to stirred concentrated nitric acid (55 ml) at 5°-10° C. and the mixture was stirred for 2 hours at 20°-25° C. The deep yellow solution was poured onto ice and extracted with dichloromethane. The extract was dried and evaporated and the residue was chromatographed on silica in ethyl acetate-hexane (1:4) to isolate the minor product.

1. additionThe deep yellow solution was poured onto ice
2. extractionextracted with dichloromethane
3. customThe extract was dried
4. customevaporated
5. customthe residue was chromatographed on silica in ethyl acetate-hexane (1:4)
6. customto isolate the minor product