Ammonium Chloride → HCID 19102569, compound

Participants

Reaction Steps

A solution of 3-[2(E)-(quinolin-2-yl)ethenyl] benzaldehyde (5.9 g, 22.8 mmol) in tetrahydrofuran (20 ml) was added to a stirred solution of phenyl magnesium bromide [prepared from bromobenzene (4.3 g, 27.4 mmol) and magnesium turnings(0.66 g, 27.4 mg atom) in tetrahydrofuran (50 ml) at ca 40° C.] at 10°-15° C. The dark solution was stirred for 1 hour at room temperature, poured onto saturated ammonium chloride solution and extracted with dichloromethane. The extract was dried and evaporated and the residue was crystallised from ethyl acetate.

Provenance & Evidence