4-(Aminomethyl)piperidine → HCID 13402008, compound

Participants

Reaction Steps

A mixture of 0.52 g (0.19 mmole) of 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxo-1,8 -naphthyridine-3-carboxylic acid, 150 mL acetonitrile, and 0.66 g (5.76 mmole) 4-aminomethylpiperidine [J. Med. Chem., 9 441 (1966)] was stirred at room temperature for four days. The reaction was filtered and the precipitate dissolved in 500 mL of aqueous ammonium hydroxide at pH 10.5. The solution was filtered and the solvent was removed at reduced pressure. The precipitate was washed with 5 mL of water, then ether until dry to give 0.42 g of 7-[4-(aminomethyl)-1-piperidinyl]-1-ethyl-6-fluoro-1,4-dihydro-4 -oxo-1,8-naphthyridine-3-carboxylic acid, mp 203°-206° C.

Provenance & Evidence