Hydrochloric Acid → HCID 461417, compound

Participants

Reaction Steps

7-[3-(1-[N-tert-butoxycarbonylamino]ethyl)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4 -dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid isomer B (0.74 g, 0.0016 mole) in ethanol (35 mL)/1N HCl (14 mL) was heated at 90° for two hours. The reaction was cooled to room temperature and the solvent was removed under reduced pressure. The residue was treated with isopropyl alcohol twice and the solvent was removed under reduced pressure. The solid was dried in an oven under vacuum at 70° for 60 hours. The solid was then stirred up in water, filtered, and the filtrate was placed on a freeze drying apparatus for 16 hours. 7-[3-(1-aminoethyl)-1-pyrrolidinyl]-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8 -naphthyridine-3-carboxylic acid isomer B was obtained (0.63 g, 80%) as a pale yellow solid, mp 281°-284° (dec).

Provenance & Evidence