HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → HCID 13565852, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Ethyl 4-[6-(cyclopropylamino)-3-nitro-2-pyridinyl]-1-piperazinecarboxylate | HCID 13565851 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 13565852 | HCID 13565852 | — |
Reaction Steps
A solution of 64.0 g (0.19 mole) of 4-[6-(cyclopropylamino)-3-nitro-2-pyridinyl]-1 -piperazinecarboxylic acid, ethyl ester, 115 mL of acetic anhydride and 115 mL of acetic acid was heated on a steam bath for 36 hours. The solvents were removed in vacuo, the residue was triturated with a mixture of ethanol and toluene which was also evaporated in vacuo to give 68.3 g of the title compound, mp 90°-93° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05281612 |
| Source dataset | uspto-grants-1994_01 |
| ORD ID | ord-0bfd7b01b3b449aab890673a06fee009 |
| Source note | uspto-grants-1994_01 |