Hydroxyamine hydrochloride → HCID 85126173, compound

Participants

Reaction Steps

Hydroxylamine hydrochloride (5.58 g, 0.076 mole) was added to a solution of 4-acetyl-1-benzyl-2-pyrrolidinone (15.0 g, 0.069 mole) in pyridine (250 mL) and the reaction mixture was heated at 40° with stirring under nitrogen for 18 hours. The solvent was removed under reduced pressure at 65° and the residue was dissolved in chloroform (900 mL), washed with water (500 mL), 0.5M HCl (3×500 mL), and dried (MgSO4). The solvent was removed under reduced pressure to give 1-benzyl-4-(1-hydroxyiminoethyl)-2-oxo-pyrrolidine (16.7 g, quant) as a brown solid.

Provenance & Evidence