HCID 86745671, compound → HCID 19102849, compound

HRID 1198615Notes

Reaction equation

HRID 1198615 reaction equation
C([O:3][C:4]([C:6]1[C:36](=[O:37])[C:35]([C:38]([O:40]CC)=[O:39])=[CH:34][C:9]2[N:10]([CH2:17][C:18]3[CH:23]=[CH:22][C:21]([C:24]4[C:25]([C:30]([O:32]C)=[O:31])=[CH:26][CH:27]=[CH:28][CH:29]=4)=[CH:20][CH:19]=3)[C:11]([CH2:13][CH2:14][CH2:15][CH3:16])=[N:12][C:8]=2[CH:7]=1)=[O:5])C>[OH-].[Na+].C(O)C>[C:4]([C:6]1[C:36](=[O:37])[C:35]([C:38]([OH:40])=[O:39])=[CH:34][C:9]2[N:10]([CH2:17][C:18]3[CH:23]=[CH:22][C:21]([C:24]4[C:25]([C:30]([OH:32])=[O:31])=[CH:26][CH:27]=[CH:28][CH:29]=4)=[CH:20][CH:19]=3)[C:11]([CH2:13][CH2:14][CH2:15][CH3:16])=[N:12][C:8]=2[CH:7]=1)([OH:5])=[O:3]

Participants

4

Reactant 1

HCID 86745671HCID 86745671, compound

Product 1

HCID 19102849HCID 19102849, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

An aliquot of the triester from Step (h) (300 mg) was hydrolyzed by stirring it in a mixture of 12 ml of 10% sodium hydroxide and 12 ml of ethanol for 6 h at 40° C. The azeotrope was distilled off, water (30 ml) was added and the resulting solution slowly acidified to pH 3 with HCl 2N. The resulting precipitated acid was isolated (mp 186, decomp.).

Workup

  1. distillationThe azeotrope was distilled off
  2. additionwater (30 ml) was added
  3. customThe resulting precipitated acid
  4. customwas isolated (mp 186, decomp.)

Sources & evidence

ORD record
ord-f2c61023845b4325bb9a7be422bccbee
Source dataset
uspto-grants-1994_01
Patent number
US05281615

Reaction notes

Loading…