HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 14519884, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | 4-Methyl-2-(phenylmethoxy)benzenemethanol | HCID 818692 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | HCID 14519884 | HCID 14519884 | 92.9% |
Reaction Steps
A solution of crude 4-methyl-2-phenylmethoxy-benzenemethanol (20 g, 87.6 mmol) in dry benzene (100 ml) was treated with 9.1 ml (96 mmol) PBr3 at room temperature and after being stirred for 10 min the mixture was treated with 50 ml 2N NaOH solution. The organic layer was separated and dried (Na2SO4) to give 1-bromomethyl-4-methyl-2-phenylmethoxybenzene (23.7 g, 93% crude yield) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05281620 |
| Source dataset | uspto-grants-1994_01 |
| ORD ID | ord-2f83be5f9c3441f590db2edcb0889718 |
| Source note | uspto-grants-1994_01 |