Benzenesulfonyl chloride → HCID 10349512, compound

Participants

Reaction Conditions

Reaction Steps

The title compound was prepared from 5-n-butyl-2,4-dihydro-4-[(2'-sulfamoylbiphenyl-4-yl)methyl]-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one (from Example 13, Step C) according to the procedure of Example 14, except that a total of 2.4 equivalents of benzenesulfonyl chloride was used, and the mixture was heated at 60° C. for 4 hours. The crude produce was purified by flash chromotography on silica gel (gradient elution with 0.5-5% MeOH in CH2Cl2). The residue from evaporation of the product fractions was partitioned between CH2Cl2 and 1N HCl. The organic phase was dried (Na2SO4), filtered, and concentrated in vacuo to give the title compound as a cream-colored, sticky solid, homogeneous by TLC in 9:1 CH2Cl2 --MeOH; mass spectrum (FAB) m/e 671 (M+1)+.

Provenance & Evidence