HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl chloroformate → HCID 10393837, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl chloroformate | HCID 10928 | — |
| Reactant | 5-n-Butyl-2,4-dihydro-4-[(2'-sulfamoylbiphenyl-4-yl)methyl]-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one | HCID 10346902 | — |
| Product | HCID 10393837 | HCID 10393837 | — |
Reaction Steps
The title compound was prepared from 5-n-butyl-2,4-dihydro-4-[(2'-sulfamoylbiphenyl-4-yl)methyl]-2-[2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one (from Example 13, Step C) and ethyl chloroformate, according to the procedure of Example 14. The crude product was flash chromatographed over silica gel (gradient elution using 0.3-5.0% MeOH/CH2Cl2) to afford the desired material as a white solid, mp 79°-81° C.; homogeneous by TLC (5% MeOH/CH2Cl2); mass spectrum (FAB) m/e 603 (M+1)+, 625 (M+Na)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05281614 |
| Source dataset | uspto-grants-1994_01 |
| ORD ID | ord-b01816c645c848c7998067b3233453e2 |
| Source note | uspto-grants-1994_01 |