HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 19102794, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Carbamic acid, [[4′-[[3-butyl-1,5-dihydro-1-[4-nitro-2-(trifluoromethyl)phenyl]-5-oxo-4H-1,2,4-triazol-4-yl]methyl][1,1′-biphenyl]-2-yl]sulfonyl]-, 1,1-dimethylethyl ester | HCID 19102789 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 19102794 | HCID 19102794 | — |
Reaction Steps
The title compound is prepared from 4-[[2'-[N-(t-butoxycarbonyl)sulfamoyl]biphenyl-4-yl]methyl]-5-n-butyl-2,4-dihydro-2-[4-nitro-2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one (from Example 21) by treatment with excess stannous chloride and concentrated hydrochloric acid in THF at 0° C. The reaction is worked up by treatment with excess sodium hydroxide, and the product is extracted with ethyl acetate. After drying over anhydrous sodium sulfate and removal of volatiles, the crude product is flash chromatographed over silica gel to afford the desired material.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05281614 |
| Source dataset | uspto-grants-1994_01 |
| ORD ID | ord-2094a83ce54243fcb638d8c7898fe0e2 |
| Source note | uspto-grants-1994_01 |