HCID 10054925, compound → HCID 10077491, compound

Participants

Reaction Steps

A mixture of 128 mg (0.2 mmol) of 4-[[2'-[N-(t-butoxycarbonyl)sulfamoyl]-biphenyl-4-yl]methyl]-5-n-butyl-2-(2-chloro-5-nitrophenyl)-2,4-dihydro-3H -1,2,4-triazol-3-one (from Example 24), 10 mg of 10% platinum oxide on carbon, and 2 mL of ethyl acetate was stirred under a hydrogen atmosphere (balloon) for 4 hours. The mixture was then filtered through Celite, and the product was chromatographed on a column of silica gel (gradient elution with 0.5-5% methanol in CH2Cl2) to yield 78 mg of the title compound as a white solid, mp 185°-188° C.; nearly homogeneous by TLC (9:1 CH2Cl2 --MeOH).

Provenance & Evidence