反应详情

A solution of 50 mg (0.10 mmol) of 4-(4-bromo-2-fluorobenzyl)-5-n-butyl-2-[2-chloro-5-(methoxycarbonyl)phenyl]-2,4-dihydro-3H-1,2,4-triazol-3-one (from Step D) in 1 mL of n-butylamine was stirred overnight at 65° C. and then evaporated in vacuo. The residue was flash chromatographed on 15 cc of silica gel (gradient elution with 1-5% MeOH in CH2Cl2) to yield 41 mg (76%) of colorless, glassy solid, mp 114°-116° C.; homogeneous by TLC (95:5 CH2Cl2 --MeOH); mass spectrum (FAB) M/e 537, 539 (M+1)+.

1. customevaporated in vacuo
2. customchromatographed on 15 cc of silica gel (gradient elution with 1-5% MeOH in CH2Cl2)
3. customto yield 41 mg (76%) of colorless, glassy solid, mp 114°-116° C.