HRID1198688

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)(C)NS(=O)(=O)c1ccccc1-c1ccc(CBr)cc1

HCID15282100

未命名化合物

结构：CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Br)c(=O)[nH]1

HCID135720080

未命名化合物

PRODUCTS

生成物

结构：CCCCc1nn(-c2cc([N+](=O)[O-])ccc2Br)c(=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(C)(C)C)cc1

HCID10077917

未命名化合物

收率 92%

PROCEDURE

实验过程

The alkylation of 2-(2-bromo-5-nitrophenyl)-5-n-butyl-2,4-dihydro-3H-1,2,4-triazol-3-one (from Step A) with [2'-(N-t-butylsulfamoyl)biphenyl-4-yl]methyl bromide (from Example 7) was carried out according to the procedure of Example 8, Step A, to give a 92% yield of the title compound as a yellow solid, mp 126°-128° C.; homogeneous by TLC in 98:2 CH2Cl2 --MeOH; mass spectrum (FAB) m/e 642, 644 (M+1)+.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d629c9888b564344abbb34e62ef5d050
来源数据集: uspto-grants-1994_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05281614
来源说明: uspto-grants-1994_01

反应 SMILES

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[N:11]1[C:15](=[O:16])[NH:14][C:13]([CH2:17][CH2:18][CH2:19][CH3:20])=[N:12]1.[C:21]([NH:25][S:26]([C:29]1[CH:34]=[CH:33][CH:32]=[CH:31][C:30]=1[C:35]1[CH:40]=[CH:39][C:38]([CH2:41]Br)=[CH:37][CH:36]=1)(=[O:28])=[O:27])([CH3:24])([CH3:23])[CH3:22]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[N:11]1[C:15](=[O:16])[N:14]([CH2:41][C:38]2[CH:39]=[CH:40][C:35]([C:30]3[CH:31]=[CH:32][CH:33]=[CH:34][C:29]=3[S:26](=[O:28])(=[O:27])[NH:25][C:21]([CH3:22])([CH3:24])[CH3:23])=[CH:36][CH:37]=2)[C:13]([CH2:17][CH2:18][CH2:19][CH3:20])=[N:12]1