Propionyl bromide → HCID 9810305, compound

Participants

Reaction Steps

Propionyl bromide was reacted with 2-[5-amino-2-(trifluoromethyl)phenyl]-4-[[2'-[N-(t-butoxycarbonyl)sulfamoyl]biphenyl-4-yl]methyl]-5-n-butyl-2,4-dihydro-3H-1,2,4-triazol-3-one (from Step F) according to the method of Example 26. Purification by silica gel flash chromatography (gradient elution with 0.5-5% MeOH in CH2Cl2) followed by semi-preparative HPLC (Zorbax C8 reverse phase column, elution with 60:40 and then 65:35 MeCN--H2O) gave 13 mg (52%) of the title compound as a solid, mp 158°-161° C.; homogeneous by TLC in 95:5 CH2Cl2 --MeOH; mass spectrum (FAB) m/e 714 (M+2Li)+.

Provenance & Evidence