HuagongsheHuagongshe Chemistry Print Report · For research reference only
4'-(Bromomethyl)-N-t-butyl-3'-fluoro-2-biphenylsulfonamide → 2-(2-Bromo-5-nitrophenyl)-4-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]methyl]-5-n-butyl-2,4-dihydro-3H-1,2,4-triazol-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4'-(Bromomethyl)-N-t-butyl-3'-fluoro-2-biphenylsulfonamide | HCID 10046521 | — |
| Reactant | 2-(2-Bromo-5-nitrophenyl)-5-n-butyl-2,4-dihydro-3H-1,2,4-triazol-3-one | HCID 135720080 | — |
| Product | 2-(2-Bromo-5-nitrophenyl)-4-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]methyl]-5-n-butyl-2,4-dihydro-3H-1,2,4-triazol-3-one | HCID 10349405 | 93% |
Reaction Steps
The alkylation of 2-(2-bromo-5-nitrophenyl)-5-n-butyl-2,4-dihydro-3H-1,2,4-triazol-3-one (from Example 30, Step A) with [3-fluoro-2'-(N-t-butylsulfamoyl)-biphenyl-4-yl]methyl bromide (from Step B) was carried out according to the procedure of Example 8, Step A, to give a 93% yield of the title compound as a stiff, brownish foam, mp 137°-139° C., homogeneous by TLC in 98:2 CH2Cl2 --MeOH; mass spectrum (FAB) m/e 666, 668 (M+Li)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05281614 |
| Source dataset | uspto-grants-1994_01 |
| ORD ID | ord-f5b1568060854c3eb224c8bfe4b8d97c |
| Source note | uspto-grants-1994_01 |