HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 5-n-Butyl-2,4-dihydro-4-[(3-fluoro-2'-sulfamoylbiphenyl-4-yl)methyl]-2-[5-nitro-2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Anisole | HCID 7519 | — |
| Reactant | 5-n-Butyl-4-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]methyl]-2,4-dihydro-2-[5-nitro-2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one | HCID 11764838 | — |
| Product | 5-n-Butyl-2,4-dihydro-4-[(3-fluoro-2'-sulfamoylbiphenyl-4-yl)methyl]-2-[5-nitro-2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one | HCID 19939372 | 94% |
Reaction Steps
Reaction of 5-n-butyl-4-[[2'-(N-t-butylsulfamoyl)-3-fluorobiphenyl-4-yl]methyl]-2,4-dihydro-2-[5-nitro-2-(trifluoromethyl)phenyl]-3H-1,2,4-triazol-3-one (from Step A) with trifluoroacetic acid in the presence of anisole according to the procedure of Example 28, Step G, gave a 94% yield of the title compound as a pale yellow foam, homogeneous by TLC (95:5 CH2Cl2 --MeOH); mass spectrum (FAB) m/e 594 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05281614 |
| Source dataset | uspto-grants-1994_01 |
| ORD ID | ord-59aa8038e7ca4626bbf6f0a3bb471032 |
| Source note | uspto-grants-1994_01 |