HCID 10484475, compound → HCID 10258462, compound

Participants

Reaction Steps

A mixture of 313 mg (0.475 mmol) of 4-[[2'-[N-(t-butoxycarbonyl)sulfamoyl]-3-fluorobiphenyl-4-yl]methyl]-5-n-butyl-2-(2-chloro-5-nitrophenyl)-2,4-dihydro-3H-1,2,4-triazol-3-one (from Step B), 10 mg of platinum oxide, and 4 mL of ethanol was shaken with hydrogen at approximately 3 atm for 2.5 hours. The mixture was filtered through Celite, and the filtrate was concentrated to dryness. The residue was flash chromatographed on about 60 cc of silica gel (gradient elution with 0.5-2% MeOH in CH2Cl2) to give a 57% yield of the title compound as a cream-colored solid, mp 208°-210° C.; homogeneous by TLC in 95:5 CH2Cl2 --MeOH.

Provenance & Evidence