Maleic Anhydride → HCID 10714790, compound

HRID 1198759Notes

Reaction equation

HRID 1198759 reaction equation
CO[CH:3](OC)[C:4]1[CH:9]=[C:8]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:7]=[CH:6][C:5]=1[CH:18](O)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.[C:28]1(=[O:34])[O:33][C:31](=[O:32])[CH:30]=[CH:29]1>C1(C)C=CC=CC=1>[CH2:11]([O:10][C:8]1[CH:9]=[C:4]2[C:5]([C:18]([C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=3)=[C:30]3[C:31](=[O:32])[O:33][C:28](=[O:34])[C:29]3=[CH:3]2)=[CH:6][CH:7]=1)[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 7923Maleic AnhydrideHCID 10666472HCID 10666472, compound

Product 1

HCID 10714790HCID 10714790, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a solution of the alcohol (112 g) from Step 1 in toluene (1.1 L) was added maleic anhydride (150 g). The reaction mixture was heated to reflux for 24 hours. After cooling to room temperature, the toluene was evaporated. The residue was triturated in EtOAc at 0° C., filtered and washed with Et2O to afford the title product as a white solid.

Workup

  1. temperatureThe reaction mixture was heated
  2. temperatureto reflux for 24 hours
  3. customthe toluene was evaporated
  4. customThe residue was triturated in EtOAc at 0° C.
  5. filtrationfiltered
  6. washwashed with Et2O

Sources & evidence

ORD record
ord-b6a369b7e1ea4fc6987a7a569dd111a2
Source dataset
uspto-grants-1994_01
Patent number
US05281720

Reaction notes

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